Tony's mentor turned adversary. Obadiah steals Stark's arc reactor technology to create a massive armored suit, leading to Iron Man's first major battle.

A vengeful engineer with his own arc reactor-powered whips. Vanko exposes weaknesses in Iron Man's technology and allies with Justin Hammer to challenge Tony.

A rival weapons manufacturer who supplies Vanko with resources to create drones and disrupt Tony’s reputation.

Although not Iron Man’s sole adversary, Loki leads the Chitauri army in an attack on New York, prompting Tony to confront intergalactic threats and push his limits.

The head of Advanced Idea Mechanics (AIM) and the true power behind the Mandarin facade. He uses the Extremis virus to enhance his abilities, presenting Iron Man with a new biological challenge.

Poses as a global terrorist but is later revealed to be a decoy set up by Killian.

An AI villain accidentally created by Tony Stark and Bruce Banner. Ultron's goal to achieve “peace” through human extinction forces Iron Man to confront the ethical implications of his inventions.

Tony confronts the Winter Soldier after discovering his role in his parents' death, leading to one of Iron Man's most emotionally charged battles.

One of Iron Man's greatest threats, Thanos battles Tony on Titan. The fight pushes Tony to his limits, as he barely survives after witnessing the scale of Thanos's power. In the final battle on Earth, Tony faces Thanos once again. This time, he sacrifices himself to wield the Infinity Stones and defeat Thanos, bringing closure to his journey.